Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | LSS | P48449 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459679 | 0.96 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL28032524 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL7876880 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAAMAPTCHRNB2 | |
| SCHEMBL8751720 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL7870367 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL16179016 | 0.76 | MEN1 (0.59) | ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL11349063 | 0.76 | CHRNB2 (0.60) | ALDH1A1SMN1; SMN2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1854417 | 0.75 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL1232308 | 0.74 | MAPT (0.49) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL513490 | 0.74 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476663-B2 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
| US-20050277628-A1 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277628-A1 | Substituted thiophene carboxamides | OTC, SLC22A8, DDC | ALDH1A1 910/4885SMN1; SMN2 1529/4885GAA 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.