Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27610043 | 0.80 | ALOX5 (0.40) | ALOX5GSK3BADRA1D | |
| SCHEMBL19277643 | 0.73 | ALOX5 (0.44) | ALOX5GSK3BADRA1D | |
| SCHEMBL19043458 | 0.71 | ALDH1A1 (0.40) | — | |
| SCHEMBL1200623 | 0.70 | NPC1 (0.48) | ALOX5HTR2AHRH1POLB | |
| SCHEMBL522925 | 0.70 | NPC1 (0.48) | ALOX5HTR2AHRH1POLB | |
| SCHEMBL4156 | 0.70 | NPC1 (0.48) | ALOX5HTR2AHRH1POLB | |
| SCHEMBL27512096 | 0.70 | ALOX5 (0.45) | ALOX5GSK3BADRA1D | |
| SCHEMBL4621986 | 0.69 | NPC1 (0.47) | ALOX5HTR2AHRH1POLB | |
| SCHEMBL4619913 | 0.69 | NPC1 (0.47) | ALOX5HTR2AHRH1POLB | |
| Hydrochloric Acid SCHEMBL27710967 | 0.69 | NPC1 (0.47) | ALOX5HTR2AHRH1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |