Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.41 |
| ▸ | AMPD2 | Q01433 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288660 | 0.88 | HTT (0.43) | ALDH1A1HPGDTSHRPOLB | |
| SCHEMBL290017 | 0.85 | KMT2A (0.43) | L3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL288186 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL288848 | 0.82 | NPSR1 (0.57) | L3MBTL1ALDH1A1GAAKMT2APKM | |
| SCHEMBL3733166 | 0.80 | TSHR (0.52) | AMPD2ALDH1A1GAATSHRKMT2A | |
| SCHEMBL22394905 | 0.77 | HCRTR1 (0.50) | HCRTR1HCRTR2KCNH2LTC4SDDB1 | |
| SCHEMBL8876707 | 0.76 | ALDH1A1 (0.50) | AMPD2DDB1CRBNL3MBTL1ALDH1A1 | |
| SCHEMBL14828739 | 0.76 | TSHR (0.51) | AMPD2ALDH1A1GAATSHRKMT2A | |
| SCHEMBL14828734 | 0.76 | ALDH1A1 (0.49) | AMPD2DDB1CRBNL3MBTL1ALDH1A1 | |
| SCHEMBL14665104 | 0.74 | TSHR (0.52) | AMPD2ALDH1A1GAATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074518-A1 | COMBINATIONS OF PROLINAMIDE P2X7 MODULATORS WITH FURTHER THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |