Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288660 | 0.85 | HTT (0.43) | PTGER4PTGER2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4460381 | 0.85 | HCRTR1 (0.41) | KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL288186 | 0.84 | SMN1; SMN2 (0.46) | KMT2AMEN1PTGER4PTGER2NR4A2 | |
| SCHEMBL288848 | 0.81 | NPSR1 (0.57) | KMT2AMEN1PTGER4PTGER2FAAH | |
| SCHEMBL289516 | 0.81 | FAAH (0.44) | PTGER4FAAHALDH1A1L3MBTL1FEN1 | |
| SCHEMBL11888874 | 0.68 | ALDH1A1 (0.56) | KMT2AMEN1FAAHALDH1A1SMN1; SMN2 | |
| SCHEMBL288978 | 0.68 | P2RX7 (0.55) | KMT2AMEN1ALDH1A1SIGMAR1 | |
| SCHEMBL1611845 | 0.68 | P2RX7 (0.55) | KMT2AMEN1ALDH1A1SIGMAR1 | |
| SCHEMBL30601818 | 0.67 | MEN1 (0.46) | KMT2AMEN1HCAR2NR4A2ALDH1A1 | |
| SCHEMBL26123725 | 0.67 | MEN1 (0.46) | KMT2AMEN1HCAR2NR4A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128102-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |