Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460381 | 0.82 | HCRTR1 (0.41) | KMT2AMEN1L3MBTL1ALDH1A1GAA | |
| SCHEMBL290017 | 0.81 | KMT2A (0.43) | SIGMAR1KMT2AMEN1L3MBTL1PTGER4 | |
| SCHEMBL288186 | 0.79 | SMN1; SMN2 (0.46) | SIGMAR1KMT2AMEN1PTGER4PTGER2 | |
| SCHEMBL10689115 | 0.75 | NPSR1 (0.51) | NPSR1SIGMAR1KMT2AMEN1L3MBTL1 | |
| SCHEMBL288660 | 0.75 | HTT (0.43) | PTGER4PTGER2ALDH1A1KDM4EMAPT | |
| SCHEMBL288451 | 0.71 | GYS1 (0.58) | NPSR1CMA1SIGMAR1KMT2AALDH1A1 | |
| SCHEMBL1612182 | 0.71 | GYS1 (0.58) | NPSR1CMA1SIGMAR1KMT2AALDH1A1 | |
| SCHEMBL11080677 | 0.70 | L3MBTL1 (0.52) | NPSR1KMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL26128078 | 0.70 | L3MBTL1 (0.57) | NPSR1KMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL8115518 | 0.70 | CMA1 (0.79) | CMA1SIGMAR1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128102-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |