Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290017 | 0.84 | KMT2A (0.43) | SMN1; SMN2PTGER4PTGER2KMT2ANR4A2 | |
| SCHEMBL4460381 | 0.82 | HCRTR1 (0.41) | KMT2AALDH1A1GAAMEN1 | |
| SCHEMBL288660 | 0.77 | HTT (0.43) | SMN1; SMN2LMNAPTGER4PTGER2KDM4E | |
| SCHEMBL11099626 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAATMKDM4EALDH1A1 | |
| SCHEMBL289453 | 0.70 | P2RX7 (0.60) | SMN1; SMN2PTGER4S1PR1GRK5CDK8 | |
| SCHEMBL1611778 | 0.70 | P2RX7 (0.60) | SMN1; SMN2PTGER4S1PR1GRK5CDK8 | |
| SCHEMBL15967787 | 0.69 | HSD11B1 (0.53) | SMN1; SMN2LMNAS1PR1GRK5CDK8 | |
| SCHEMBL15967788 | 0.69 | HSD11B1 (0.53) | SMN1; SMN2LMNAS1PR1GRK5CDK8 | |
| SCHEMBL27723156 | 0.68 | ATM (0.48) | SMN1; SMN2LMNAPTGER4S1PR1GRK5 | |
| SCHEMBL4698249 | 0.67 | KDM4E (0.70) | SMN1; SMN2LMNAS1PR1GRK5CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128102-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |