Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460381 | 0.88 | HCRTR1 (0.41) | TSHRALDH1A1POLBHPGD | |
| SCHEMBL290017 | 0.85 | KMT2A (0.43) | ALDH1A1PTGER4PTGER2SMN1; SMN2KDM4E | |
| SCHEMBL288186 | 0.77 | SMN1; SMN2 (0.46) | HTTALDH1A1PTGER4PTGER2LMNA | |
| SCHEMBL288848 | 0.75 | NPSR1 (0.57) | ALDH1A1PTGER4PTGER2LMNASMN1; SMN2 | |
| SCHEMBL10695834 | 0.73 | ALDH1A1 (0.43) | CNR1CNR2ALDH1A1 | |
| SCHEMBL28271896 | 0.71 | AMPD2 (0.39) | TSHRALDH1A1LMNAMAPT | |
| SCHEMBL3733166 | 0.70 | TSHR (0.52) | TSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8876707 | 0.66 | ALDH1A1 (0.50) | TSHRALDH1A1HPGD | |
| SCHEMBL14828739 | 0.66 | TSHR (0.51) | TSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14828734 | 0.65 | ALDH1A1 (0.49) | TSHRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128102-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |