Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 11/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450029 | 0.89 | CYSLTR2 (0.36) | LTB4RLTB4R2CYSLTR2CYSLTR1S1PR2 | |
| SCHEMBL4450311 | 0.84 | CYSLTR2 (0.36) | LTB4RLTB4R2CYSLTR2CYSLTR1S1PR2 | |
| SCHEMBL4453277 | 0.82 | LTB4R (0.47) | LTB4RLTB4R2TSHR | |
| SCHEMBL13956434 | 0.82 | LTB4R (0.47) | LTB4RLTB4R2TSHR | |
| SCHEMBL4447372 | 0.81 | BRD4 (0.34) | PPARA | |
| SCHEMBL4460104 | 0.81 | BRD4 (0.34) | PPARA | |
| SCHEMBL13956465 | 0.79 | TSHR (0.56) | LTB4RLTB4R2ALDH1A1TSHRPPARA | |
| SCHEMBL13956629 | 0.79 | PPARA (0.46) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARA | |
| SCHEMBL4460417 | 0.78 | PPARG (0.39) | LTB4RLTB4R2TSHRPPARA | |
| SCHEMBL4450816 | 0.78 | ALDH1A1 (0.37) | ALDH1A1LMNAPOLBRECQLHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |