Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414295 | 0.86 | HRH4 (0.53) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3408025 | 0.86 | HTR1A (0.50) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3407418 | 0.84 | ADRA2A (0.49) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3411774 | 0.84 | ADRA2A (0.48) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3408030 | 0.84 | HTR2A (0.65) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3407775 | 0.82 | DRD2 (0.57) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL3411352 | 0.79 | HRH4 (0.64) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL23242587 | 0.75 | DRD2 (0.60) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL5326459 | 0.74 | HTR7 (0.45) | HRH4HTR2AADRA2AHTR1ADRD2 | |
| SCHEMBL7414308 | 0.72 | HRH4 (0.82) | HRH4HTR2AADRA2AHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088147-A1 | Dibenzo-condensed azepine, diazepine, oxazepine and thiazepine derivatives as muscarinic agonists and methods of treatment of neuropsychiatric disorders | Arcadia Pharmaceuticals Inc. (US) | 2009-08-12 | — | — | EP | disclosed |