Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445208 | 0.75 | PDE4A (0.54) | ADORA1ADORA2AADORA2BHSD17B10HPGD | |
| SCHEMBL30012845 | 0.69 | ADORA2B (0.39) | ADORA1ADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL3227594 | 0.69 | PDE4A (0.55) | ADORA1ADORA2AADORA2BHSD17B10HPGD | |
| SCHEMBL3223903 | 0.68 | PDE4A (0.55) | ADORA1ADORA2AADORA2BHSD17B10HPGD | |
| SCHEMBL9173396 | 0.67 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BHPGDKDM4E | |
| SCHEMBL8118476 | 0.66 | ADORA1 (1.00) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL2958488 | 0.66 | ADORA2A (0.58) | ADORA1ADORA2AADORA2BHSD17B10HPGD | |
| SCHEMBL5229734 | 0.65 | ADORA2B (1.00) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL3231032 | 0.65 | PDE4A (0.50) | ADORA1ADORA2AADORA2BHSD17B10HPGD | |
| SCHEMBL5227784 | 0.65 | ADORA2B (0.72) | ADORA1ADORA2AADORA2BHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579354-B2 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2009-08-25 | — | — | US | disclosed |
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | ADORA1, ADORA2A, ADORA3 | ADORA1 1/4885ADORA2A 2/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.