Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.45 |
| ▸ | SLC5A7 | Q9GZV3 | 8/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463994 | 0.84 | IGF1R (0.31) | IGF1RHRH4NOS3NOS1NOS2 | |
| SCHEMBL1792954 | 0.83 | IGF1R (0.47) | IGF1RSLC5A7 | |
| SCHEMBL1792577 | 0.78 | IGF1R (0.46) | IGF1RSLC5A7 | |
| SCHEMBL1792505 | 0.78 | IGF1R (0.62) | IGF1RSLC5A7 | |
| SCHEMBL4457341 | 0.77 | SLC5A7 (0.44) | IGF1RSLC5A7HRH3 | |
| SCHEMBL2298500 | 0.77 | IGF1R (0.44) | IGF1RSLC5A7 | |
| SCHEMBL1790427 | 0.77 | ALDH1A1 (0.36) | IGF1RNOS3NOS1NOS2HRH3 | |
| SCHEMBL4457078 | 0.76 | IGF1R (0.41) | IGF1RHRH4HRH3 | |
| SCHEMBL4469769 | 0.72 | NUDT1 (0.46) | IGF1RSLC5A7NOS1 | |
| SCHEMBL1792455 | 0.69 | IGF1R (0.57) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |