Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463976 | 0.84 | IGF1R (0.45) | IGF1RHRH4NOS3NOS1NOS2 | |
| SCHEMBL4457348 | 0.77 | HRH3 (0.35) | IGF1R | |
| SCHEMBL4469774 | 0.72 | NUDT1 (0.49) | — | |
| SCHEMBL1792954 | 0.69 | IGF1R (0.47) | IGF1R | |
| SCHEMBL4471578 | 0.69 | IGF1R (0.41) | IGF1R | |
| SCHEMBL4462898 | 0.68 | KDM4E (0.39) | — | |
| SCHEMBL4457341 | 0.61 | SLC5A7 (0.44) | IGF1R | |
| SCHEMBL1715078 | 0.61 | PPARA (0.40) | NOS3NOS1NOS2 | |
| SCHEMBL4457078 | 0.59 | IGF1R (0.41) | IGF1RHRH4 | |
| SCHEMBL459183 | 0.59 | PPARA (0.43) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |