Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471578 | 0.86 | IGF1R (0.41) | IGF1RHRH3SMN1; SMN2KDM4E | |
| SCHEMBL4457348 | 0.84 | HRH3 (0.35) | IGF1RHRH3 | |
| SCHEMBL1788923 | 0.82 | IGF1R (0.47) | SLC5A7IGF1R | |
| SCHEMBL4461468 | 0.80 | PTPN1 (0.47) | IGF1RHRH3ADORA2AADORA1 | |
| SCHEMBL1790427 | 0.78 | ALDH1A1 (0.36) | IGF1RHRH3SMN1; SMN2 | |
| SCHEMBL4463976 | 0.77 | IGF1R (0.45) | SLC5A7IGF1RHRH3 | |
| SCHEMBL1791206 | 0.75 | IGF1R (0.61) | SLC5A7IGF1R | |
| SCHEMBL4457078 | 0.75 | IGF1R (0.41) | IGF1RHRH3 | |
| SCHEMBL4469769 | 0.72 | NUDT1 (0.46) | SLC5A7IGF1RHTTSMN1; SMN2KDM4E | |
| SCHEMBL14310329 | 0.71 | IGF1R (0.66) | SLC5A7IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |