Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTPA | P49638 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466403 | 0.81 | TTPA (0.36) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL15107363 | 0.79 | — | — | |
| SCHEMBL4468788 | 0.74 | KMT2A (0.38) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL4466864 | 0.69 | ALOX5 (0.35) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL4466861 | 0.69 | ALOX5 (0.35) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL10473129 | 0.68 | TTPA (0.38) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL8537504 | 0.67 | TTPA (0.37) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL4472745 | 0.67 | PTGS1 (0.37) | ALOX5 | |
| SCHEMBL9285775 | 0.66 | TTPA (0.36) | TTPAMEN1KMT2APDE4APDE3A | |
| SCHEMBL8534827 | 0.66 | TTPA (0.39) | TTPAMEN1KMT2APDE4APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | claimed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | claimed |
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | ALOX15B, ALOX5, ALOX15 | TTPA 255/4885MEN1 4420/4885KMT2A 3967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.