Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | STAT3 | P40763 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.51 |
| ▸ | WNT3A | P56704 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444537 | 0.87 | FLT3 (0.65) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| SCHEMBL42245 | 0.87 | FLT3 (0.65) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| SCHEMBL27541852 | 0.85 | FLT3 (0.63) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4258298 | 0.85 | FLT3 (0.63) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| Hydrazine SCHEMBL27690059 | 0.84 | FLT3 (0.61) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| Hydrazine SCHEMBL27956766 | 0.82 | FLT3 (0.59) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| SCHEMBL29805260 | 0.81 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| Methylene Chloride SCHEMBL28057236 | 0.81 | CTNNB1 (0.60) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| SCHEMBL498053 | 0.81 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 | |
| SCHEMBL27730186 | 0.81 | KDM4E (0.51) | KDM4ESTAT3HIF1AYTHDC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | KDM4E 656/4885STAT3 58/4885HIF1A 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.