Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44399 | 0.88 | KCNH2 (0.40) | SMN1; SMN2TP53MAPK1MAPTHTT | |
| SCHEMBL44571 | 0.87 | NOTUM (0.47) | SMN1; SMN2TP53MAPK1RAB9ANPC1 | |
| SCHEMBL44656 | 0.86 | MAPT (0.41) | RAB9AHPGDMAPTALDH1A1LMNA | |
| SCHEMBL44333 | 0.83 | L3MBTL1 (0.58) | SMN1; SMN2TP53MAPK1RAB9ANPC1 | |
| SCHEMBL44657 | 0.79 | KDM4E (0.52) | SMN1; SMN2TP53MAPK1RAB9ANPC1 | |
| SCHEMBL44745 | 0.79 | HDAC6 (0.41) | L3MBTL1 | |
| SCHEMBL44391 | 0.76 | THRB (0.44) | MAPTTHRBTSHRKMT2A | |
| SCHEMBL44465 | 0.74 | MAPK1 (0.45) | SMN1; SMN2TP53MAPK1RAB9ANPC1 | |
| SCHEMBL12377806 | 0.74 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53MAPK1RAB9ANPC1 | |
| SCHEMBL60213 | 0.74 | L3MBTL1 (0.55) | SMN1; SMN2TP53MAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |