SCHEMBL446675

SCHEMBL446675

C=C(Cc1ccc(Nc2ccccc2)cc1)C(N)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.51
GAA P10253 2/20 0.51
GFER P55789 1/20 0.51
CASP3 P42574 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
MAPK13 O15264 1/20 0.44
MAPK12 P53778 1/20 0.44
MAPK11 Q15759 1/20 0.44
MAPK14 Q16539 1/20 0.44
SIRT2 Q8IXJ6 1/20 0.44
ALDH1A1 P00352 4/20 0.43
ALOX12 P18054 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
TSHR P16473 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
ALOX15 P16050 1/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
MAPK1 P28482 1/20 0.43
PTGS2 P35354 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5073494 0.86 CASP3 (0.48) MAPTGAAGFERCASP3SENP7
SCHEMBL208487 0.84 CES1 (0.54) GAAALDH1A1L3MBTL1TSHRPTGS1
SCHEMBL27463865 0.82 MAPT (0.58) MAPTGAAGFERCASP3SENP7
Ethylene SCHEMBL6400163 0.82 CES1 (0.52) GAAALDH1A1L3MBTL1TSHRPTGS1
Diphenylamine SCHEMBL27511663 0.78 MAPT (0.71) MAPTGAAGFERCASP3SENP7
SCHEMBL447008 0.78 CXCL8 (0.45) MAPTGAAGFERSIRT2ALDH1A1
SCHEMBL27873258 0.77 MAPK13 (0.58) MAPTGAAGFERCASP3SENP7
Diethylamine SCHEMBL6005225 0.77 CES2 (0.42) TSHREPHX2POLBMEN1KMT2A
SCHEMBL31114527 0.77 SRD5A2 (0.55) EPHX2LTA4H
SCHEMBL17455777 0.76 WNT3A (0.44) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4361187-A1 VISCOSITY INDEX IMPROVER, REFRIGERATOR OIL, AND WORKING FLUID COMPOSITION FOR REFRIGERATORS Sanyo Chemical Industries, Ltd. (JP) 2024-05-01 EP disclosed
US-20150045272-A1 GREASE COMPOSITION SHELL OIL COMPANY 2015-02-12 US disclosed
US-20120108481-A1 LUBRICATING COMPOSITION SHELL OIL COMPANY 2012-05-03 US disclosed
US-20120065109-A1 Lubricating oil composition for transmission NIPPON OIL CORPORATION (JP) 2012-03-15 US disclosed