SCHEMBL447008

SCHEMBL447008

C=C(Cc1ccccc1Nc1ccccc1)C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCL8 P10145 4/20 0.45
PTGS2 P35354 3/20 0.43
TTR P02766 2/20 0.43
AKR1B10 O60218 1/20 0.43
UGT1A9 O60656 1/20 0.43
TRPA1 O75762 1/20 0.43
ABCB11 O95342 1/20 0.43
MT-CO2 P00403 1/20 0.43
ALB P02768 1/20 0.43
UGT1A6 P19224 1/20 0.43
UGT1A1 P22309 1/20 0.43
PTGS1 P23219 1/20 0.43
CXCR1 P25024 1/20 0.43
ADRA1A P35348 1/20 0.43
AGTR2 P50052 1/20 0.43
NR1I3 Q14994 1/20 0.43
SLC22A6 Q4U2R8 1/20 0.43
NR1H4 Q96RI1 1/20 0.43
UGT1A7 Q9HAW7 1/20 0.43
UGT1A10 Q9HAW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3843305 0.83 CXCL8 (0.50) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL29622781 0.80 CXCL8 (0.67) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL361662 0.80 CXCL8 (0.67) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL28534880 0.78 CXCL8 (0.65) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL446675 0.78 MAPT (0.51) PTGS2PTGS1SIRT2MAPTGAA
SCHEMBL13883938 0.77 PTGS2 (0.44) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL3839168 0.77 PKM (0.50) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL530311 0.76 FABP4 (0.59) PTGS1FABP4SIRT2MAPTMEN1
SCHEMBL11586302 0.76 HDAC8 (0.52) CXCL8PTGS2TTRAKR1B10UGT1A9
SCHEMBL16539268 0.74 SIRT2 (0.48) CXCL8MT-CO2FABP4SIRT2KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4361187-A1 VISCOSITY INDEX IMPROVER, REFRIGERATOR OIL, AND WORKING FLUID COMPOSITION FOR REFRIGERATORS Sanyo Chemical Industries, Ltd. (JP) 2024-05-01 EP disclosed
US-20150045272-A1 GREASE COMPOSITION SHELL OIL COMPANY 2015-02-12 US disclosed
US-8728997-B2 Lubricating oil composition NIPPON OIL CORPORATION (JP) 2014-05-20 US disclosed
US-20120108481-A1 LUBRICATING COMPOSITION SHELL OIL COMPANY 2012-05-03 US disclosed
US-20120065109-A1 Lubricating oil composition for transmission NIPPON OIL CORPORATION (JP) 2012-03-15 US disclosed
US-20090131291-A1 LUBRICATING OIL COMPOSITION NIPPON OIL CORPORATION (JP) 2009-05-21 US disclosed