Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5249514 | 0.81 | PRCP (0.55) | PRCPDRD2DRD1CA1CA2 | |
| SCHEMBL8023234 | 0.79 | MAOA (0.48) | PRCPDRD2HTR1BHTR6CHRNB1 | |
| SCHEMBL5249358 | 0.77 | DRD1 (0.50) | PRCPDRD2DRD1SLC6A2SLC6A4 | |
| SCHEMBL5244479 | 0.74 | CA1 (0.55) | PRCPDRD2DRD1CA1CA2 | |
| SCHEMBL5244066 | 0.74 | DRD1 (0.50) | PRCPDRD2DRD1CA1CA2 | |
| SCHEMBL5246879 | 0.74 | PRCP (0.50) | PRCPDRD2DRD1CA1CA2 | |
| SCHEMBL7596672 | 0.73 | PRCP (0.69) | PRCPDRD2DRD1SLC6A2SLC6A4 | |
| SCHEMBL5244484 | 0.72 | SMN1; SMN2 (0.52) | PRCPDRD2DRD1CA1CA2 | |
| SCHEMBL8027330 | 0.71 | MAOA (0.48) | DRD2HTR1BHTR6SLC6A2SLC6A4 | |
| SCHEMBL19453885 | 0.69 | ESR1 (0.55) | PRCPDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246806-B1 | ARLY- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR TECHNOLOGY INC (US) | 2008-02-27 | — | — | EP | claimed |
| EP-1819337-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR Technology, Inc. (US) | 2007-08-22 | — | — | EP | claimed |
| WO-2006058016-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-06-01 | — | — | WO | claimed |
| US-20060111395-A1 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | AMR TECHNOLOGY, INC. (US) | 2006-05-25 | — | — | US | claimed |
| US-20060111394-A1 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | ALBANY MOLECULAR RESEARCH, INC. | 2006-05-25 | — | — | US | claimed |
| US-20040248932-A1 | Use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence | PHARMACIA & UPJOHN COMPANY | 2004-12-09 | — | — | US | claimed |
| US-6579885-B2 | For therapy of attention deficit disorder, hyperactivity disorder, anxiety, depression, post-traumatic stress disorder, supranuclear palsy, eating disorders, obsessive compulsive disorder, analgesia, nicotine addiction, Parkinsonism | ALBANY MOLECULAR RESEARCH, INC. | 2003-06-17 | — | — | US | claimed |
| EP-1246806-A1 | ARLY- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | claimed |
| US-20020143014-A1 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | BARCLAYS BANK PLC, AS THE COLLATERAL AGENT | 2002-10-03 | — | — | US | claimed |
| WO-2001032625-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | claimed |
| US-7612090-B2 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1246806-B1 | ARLY- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR TECHNOLOGY INC (US) | 2008-02-27 | — | — | EP | disclosed |
| US-7265116-B2 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | ARM TECHNOLOGY, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1819337-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR Technology, Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058016-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-06-01 | — | — | WO | disclosed |
| US-20030203920-A1 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT | 2003-10-30 | — | — | US | disclosed |
| US-6579885-B2 | For therapy of attention deficit disorder, hyperactivity disorder, anxiety, depression, post-traumatic stress disorder, supranuclear palsy, eating disorders, obsessive compulsive disorder, analgesia, nicotine addiction, Parkinsonism | ALBANY MOLECULAR RESEARCH, INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1246806-A1 | ARLY- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | disclosed |
| US-20020143014-A1 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | BARCLAYS BANK PLC, AS THE COLLATERAL AGENT | 2002-10-03 | — | — | US | disclosed |
| WO-2001032625-A1 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248932-A1 | Use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence | OPRL1, CNR2, HTR2C | PRCP 2918/4885DRD2 1013/4885DRD1 1590/4885 |
| US-20060111394-A1 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | SLC6A2, ADRA1B, TPH1 | PRCP 1926/4885DRD2 31/4885DRD1 55/4885 |
| US-20060111395-A1 | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | SLC6A2, TPH1, ADRA1B | PRCP 2029/4885DRD2 31/4885DRD1 52/4885 |
| US-20030203920-A1 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | TPH1, TPH2, HTR1A | PRCP 2125/4885DRD2 24/4885DRD1 33/4885 |
| US-20020143014-A1 | Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof | TPH1, TPH2, HTR1A | PRCP 2125/4885DRD2 24/4885DRD1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.