Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.65 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.65 |
| ▸ | SLC1A1 | P43005 | 7/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 10/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL16651962 | 0.98 | SLC7A5 (0.90) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL29805351 | 0.95 | SLC7A5 (0.95) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL8568060 | 0.93 | SLC7A5 (1.00) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL20362356 | 0.93 | — | — | |
| D-Leucine SCHEMBL9449950 | 0.93 | SLC7A5 (1.00) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL25241602 | 0.93 | SLC7A5 (1.00) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL2478164 | 0.93 | SLC7A5 (1.00) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL331557 | 0.93 | SLC7A5 (1.00) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL3888 | 0.93 | — | — | |
| D-Leucine SCHEMBL42012 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611438-B1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2020-04-01 | — | — | EP | disclosed |
| EP-2410981-B2 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20180153996-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2018-06-07 | — | — | US | disclosed |
| EP-3184099-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | Pulmatrix, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2410981-B1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX INC (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9238005-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-9233158-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20150335573-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-11-26 | — | — | US | disclosed |
| US-20150250875-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. | 2015-09-10 | — | — | US | disclosed |
| US-9119778-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20150196486-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-07-16 | — | — | US | disclosed |
| US-9061352-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20130213398-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2013-08-22 | — | — | US | disclosed |
| US-20120064126-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. (US) | 2012-03-15 | — | — | US | disclosed |