Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489535 | 0.67 | — | — | |
| SCHEMBL4495963 | 0.64 | NPC1 (0.42) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL28751195 | 0.64 | ALOX15 (0.39) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL19677 | 0.64 | — | — | |
| SCHEMBL4493865 | 0.61 | MAPT (0.46) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL3535736 | 0.61 | AHR (0.36) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL170456 | 0.60 | PLAU (0.43) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL293794 | 0.60 | ALOX15 (0.45) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL29504825 | 0.60 | PLAU (0.43) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL31312839 | 0.59 | PLAU (0.42) | NPC1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118513-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | claimed |
| US-7348341-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2008-03-25 | — | — | US | claimed |
| EP-1546130-B1 | PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASE STATES | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | claimed |
| EP-1430050-B1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | claimed |
| EP-1274701-B1 | [1,4']-BIPIPERIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2005-06-29 | — | — | EP | claimed |
| US-6903115-B2 | Bipiperidine compounds | ASTRAZENECA AB (SE) | 2005-06-07 | — | — | US | claimed |
| US-20040102432-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | claimed |
| JP-2004508355-A | — | — | 2004-03-18 | — | — | JP | claimed |
| US-20040014783-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2004-01-22 | — | — | US | claimed |
| US-20040006080-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2004-01-08 | — | — | US | claimed |
| US-20030166652-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2003-09-04 | — | — | US | claimed |
| EP-1322611-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-07-02 | — | — | EP | claimed |
| EP-1289956-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | claimed |
| EP-1274701-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-01-15 | — | — | EP | claimed |
| US-20020077337-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-06-20 | — | — | US | claimed |
| WO-2002020484-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-03-14 | — | — | WO | claimed |
| WO-2001092227-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-06 | — | — | WO | claimed |
| WO-2001077101-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-18 | — | — | WO | claimed |
| US-4581356-A | HYPOTENSIVE AND ANTIULCER AGENTS; ANTICOAGULANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-04-08 | — | — | US | claimed |
| EP-0122494-A2 | Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-24 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166652-A1 | Chemical compounds | CCR3, CCR1, CCR4 | NPC1 112/4885MAPT 2375/4885RAB9A 1644/4885 |
| US-20020077337-A1 | Chemical compounds | CCR3, CCR1, CCR4 | NPC1 823/4885MAPT 2039/4885RAB9A 2344/4885 |
| US-20090118513-A1 | Chemical Compounds | CCR3, CCR1, CCR4 | NPC1 887/4885MAPT 2117/4885RAB9A 2189/4885 |
| US-20040102432-A1 | Chemical compounds | CCL11, HRH1, HRH4 | NPC1 842/4885MAPT 3842/4885RAB9A 1454/4885 |
| US-20040006080-A1 | Chemical compounds | CCR3, CCR1, CCR4 | NPC1 823/4885MAPT 2039/4885RAB9A 2344/4885 |
| US-20040014783-A1 | Chemical compounds | CCR3, CCR1, CCR4 | NPC1 823/4885MAPT 2039/4885RAB9A 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.