SCHEMBL4469300

SCHEMBL4469300

Cc1cc2c(c(C)c1O)C1(CC2(C)C)CC(C)(C)c2cc(C)c(O)c(C)c21

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.36
ACHE P22303 2/20 0.35
CYP1A2 P05177 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
ALDH1A1 P00352 1/20 0.30
GPR35 Q9HC97 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10001261 0.85 ACHE (0.35) HNF4AACHE
SCHEMBL4459436 0.82 HNF4A (0.35) HNF4AACHECYP1A2CA1CA2
SCHEMBL23406091 0.82 HNF4A (0.35) HNF4AACHECA1CA2
SCHEMBL9327968 0.82 HNF4A (0.35) HNF4AACHECA1CA2
SCHEMBL6932829 0.82 RXRA (0.31) HNF4A
SCHEMBL16203376 0.81 HNF4A (0.34) HNF4AACHE
SCHEMBL6118523 0.80 ACHE (0.39) HNF4AACHECA1CA2
SCHEMBL6224833 0.79 HNF4A (0.50) HNF4AACHECYP1A2
SCHEMBL24053483 0.78 HNF4A (0.35) HNF4AACHECYP1A2ALDH1A1
SCHEMBL21565061 0.76 HNF4A (0.33) HNF4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567577-B1 METHOD FOR MAKING STABLE, HOMOGENEOUS MELT SOLUTIONS GEN ELECTRIC (US) 2008-05-21 EP claimed
EP-1165652-B1 POLYCARBONATES SIUTABLE FOR USE IN OPTICAL ARTICLES GEN ELECTRIC (US) 2003-12-10 EP claimed
EP-1165652-A1 POLYCARBONATES SIUTABLE FOR USE IN OPTICAL ARTICLES GENERAL ELECTRIC COMPANY (US) 2002-01-02 EP claimed
US-6248859-B1 CONTAINING SPIROBIINDANE UNITS; OPTICAL DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY 2001-06-19 US claimed
WO-2001032744-A1 POLYCARBONATES SUITABLE FOR USE IN OPTICAL ARTICLES GENERAL ELECTRIC COMPANY (US) 2001-05-10 WO claimed
US-6177537-B1 COPOLYMERS OF BISPHENOLS AND SPIRODIINDANEDIOLS GENERAL ELECTRIC COMPANY 2001-01-23 US claimed
WO-2001002462-A1 POLYCARBONATES SUITABLE FOR USE IN OPTICAL ARTICLES GENERAL ELECTRIC COMPANY (US) 2001-01-11 WO claimed
WO-2000055237-A1 POLYCARBONATES SUITABLE FOR USE IN OPTICAL ARTICLES GENERAL ELECTRIC COMPANY (US) 2000-09-21 WO claimed
US-6001953-A POLYCARBONATES CONTAIN RESIDUES OF ALICYCLIC BISPHENOLS AND HAVE PROPERTIES PARTICULARLY SUITED FOR USE IN HIGH DENSITY OPTICAL DATA STORAGE MEDIA. GENERAL ELECTRIC COMPANY (US) 1999-12-14 US claimed
US-11530230-B2 Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof ZHEJIANG UNIVERSITY (CN) 2022-12-20 US disclosed
US-20220213011-A1 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF ZHEJIANG UNIVERSITY (CN) 2022-07-07 US disclosed
US-20210163514-A1 COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF ZHEJIANG UNIVERSITY (CN) 2021-06-03 US disclosed
US-7582355-B2 Optical unit using plastic lenses FUJIFILM CORPORATION (JP) 2009-09-01 US disclosed
US-20080032086-A1 Radial Tilt Reduced Media GENERAL ELECTRIC COMPANY (US) 2008-02-07 US disclosed
US-6080833-A BIS(HYDROXYALKOXYLATED) 1,1'-SPIROBIINDAN POLYCARBONATES AND POLYESTERS POLYMERS AND CURABLE COMPOUNDS SUCH AS BIS(ACRYLATED ALKOXY)SPIROBIINDANS; ALSO POLYAMIDES AND POLYIMIDES CONTAINING SPIROBIINDAN GROUPS MITSUI CHEMICALS, INC. (JP) 2000-06-27 US disclosed
US-6060577-A FOR USE IN OPTICAL DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY (US) 2000-05-09 US disclosed
US-6028161-A EXCELLENT TRANSPARENCY, HEAT RESISTANCE AND MECHANICAL PROPERTIES AND A LOW BIREFRINGENCE, MELT FLUIDITY AND MOLDABILITY; AN OPTICAL DISK, LENS AND AN OPTICAL FIBER MITSUI CHEMICALS, INC. (JP) 2000-02-22 US disclosed
US-6001953-A POLYCARBONATES CONTAIN RESIDUES OF ALICYCLIC BISPHENOLS AND HAVE PROPERTIES PARTICULARLY SUITED FOR USE IN HIGH DENSITY OPTICAL DATA STORAGE MEDIA. GENERAL ELECTRIC COMPANY (US) 1999-12-14 US disclosed
EP-0926180-A2 A polycarbonate copolymer and applications thereof Mitsui Chemicals, Inc. (JP) 1999-06-30 EP disclosed
EP-0822545-A2 Optical component and spirobiindan polymer therefor MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-02-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213011-A1 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF TALDO1, REN, PKD1 HNF4A 4644/4885ACHE 3858/4885CYP1A2 556/4885
US-11530230-B2 Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof ORMDL3, TALDO1, TAC3 HNF4A 4395/4885ACHE 1789/4885CYP1A2 1246/4885
US-20210163514-A1 COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF ORMDL3, TALDO1, TAC3 HNF4A 4385/4885ACHE 1771/4885CYP1A2 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.