Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.52 |
| ▸ | WNT3A | P56704 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668372 | 0.84 | KDM4E (0.66) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL31148407 | 0.84 | KDM4E (0.66) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL25434894 | 0.83 | KDR (0.54) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL5792748 | 0.78 | CTNNB1 (0.67) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL6254946 | 0.78 | NPC1 (0.53) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL4469917 | 0.77 | IDO1 (0.56) | KDRFLT1KDM4EYTHDC1STAT3 | |
| SCHEMBL29444537 | 0.75 | FLT3 (0.65) | KDM4EYTHDC1STAT3HIF1ACTNNB1 | |
| SCHEMBL5353834 | 0.75 | FLT3 (0.65) | KDM4EYTHDC1STAT3HIF1ACTNNB1 | |
| SCHEMBL42245 | 0.75 | FLT3 (0.65) | KDM4EYTHDC1STAT3HIF1ACTNNB1 | |
| SCHEMBL591861 | 0.74 | KDM4E (0.62) | KDM4EYTHDC1STAT3HIF1ACTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | KDR 4234/4885FLT1 2297/4885KDM4E 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.