Sugi Predict

Sugi Predict / Compounds / SCHEMBL4470291

SCHEMBL4470291

SCHEMBL4470291

O=C(NCc1ccc(S(=O)(=O)Nc2cccc3cccnc23)s1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SLC40A1 Q9NP59 12/20 0.57
▸ NFKBIA P25963 5/20 0.57
▸ TDP1 Q9NUW8 5/20 0.57
▸ MEN1 O00255 5/20 0.57
▸ KMT2A Q03164 5/20 0.57
▸ RELA Q04206 4/20 0.57
▸ GLO1 Q04760 5/20 0.52
▸ G6PD P11413 1/20 0.52
▸ AGTR1 P30556 1/20 0.52
▸ METAP2 P50579 1/20 0.52
▸ METAP1 P53582 1/20 0.52
▸ PAX8 Q06710 1/20 0.52
▸ ATM Q13315 1/20 0.52
▸ KDR P35968 1/20 0.52
▸ CCKBR P32239 1/20 0.50
▸ NPC1 O15118 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13633769 0.75 SLC40A1 (0.70) SLC40A1NFKBIATDP1MEN1KMT2A
SCHEMBL13633913 0.75 SLC40A1 (0.68) SLC40A1NFKBIATDP1MEN1KMT2A
SCHEMBL12334602 0.74 CCKBR (0.52) TDP1MEN1KMT2ACCKBRALDH1A1
SCHEMBL7572951 0.74 KMT2A (0.54) MEN1KMT2ACCKBRALDH1A1RAB9A
SCHEMBL11995751 0.73 SLC40A1 (1.00) SLC40A1NFKBIATDP1MEN1KMT2A
SCHEMBL7460244 0.73 CCKBR (0.50) MEN1KMT2ACCKBR
SCHEMBL13633877 0.73 NFKBIA (1.00) SLC40A1NFKBIATDP1MEN1KMT2A
SCHEMBL12334072 0.73 CCKBR (0.60) TDP1MEN1KMT2ACCKBRALDH1A1
SCHEMBL8033818 0.73 HPGD (0.54) MEN1KMT2ACCKBRALDH1A1
SCHEMBL2422004 0.72 MAPK9 (0.56) MEN1KMT2AATMKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A SLC40A1 4638/4885NFKBIA 980/4885TDP1 83/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A SLC40A1 4638/4885NFKBIA 980/4885TDP1 83/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.