Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942235 | 0.97 | GPR119 (0.38) | GPR119PDE10ATRPV3GABRA1MAPK1 | |
| SCHEMBL4482079 | 0.78 | MAPK1 (0.44) | GPR119PDE10ATRPV3MAPK1 | |
| SCHEMBL629954 | 0.69 | TRPV3 (0.42) | PDE10ATRPV3MAPK1IDO1 | |
| SCHEMBL5562740 | 0.69 | USP30 (0.39) | GABRA1MAPK1IDO1 | |
| SCHEMBL17316549 | 0.68 | CACNA1G (0.40) | GPR119IDO1 | |
| SCHEMBL3540420 | 0.67 | IDO1 (0.40) | PDE10ATRPV3MAPK1IDO1 | |
| SCHEMBL29209494 | 0.67 | GAA (0.51) | — | |
| SCHEMBL16660961 | 0.67 | TRPV3 (0.40) | PDE10ATRPV3MAPK1 | |
| SCHEMBL9269519 | 0.67 | ALDH1A1 (0.44) | GPR119TRPV3MAPK1 | |
| SCHEMBL9521091 | 0.66 | GABRA5 (0.36) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |