SCHEMBL4470879

SCHEMBL4470879

O=C(Oc1ccccc1)n1c(=O)oc2ccc(Cl)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OGT O15294 1/20 1.00
ALDH1A1 P00352 4/20 0.64
TP53 P04637 1/20 0.64
ASAH1 Q13510 2/20 0.53
IDO1 P14902 7/20 0.53
KMT2A Q03164 4/20 0.51
KMO O15229 1/20 0.49
KDM4E B2RXH2 1/20 0.46
NOS3 P29474 2/20 0.44
NOS1 P29475 2/20 0.44
NOS2 P35228 2/20 0.44
MEN1 O00255 1/20 0.43
GAA P10253 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14553917 0.87 OGT (0.77) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL15788589 0.87 OGT (0.77) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL14553921 0.83 ALDH1A1 (0.71) OGTALDH1A1ASAH1IDO1KMT2A
SCHEMBL8698097 0.80 IDO1 (0.68) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL23815651 0.76 IDO1 (0.77) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL15788594 0.76 OGT (0.62) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL14553919 0.75 OGT (0.60) OGTALDH1A1ASAH1IDO1KMT2A
SCHEMBL15788588 0.74 OGT (0.59) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL14553929 0.74 OGT (0.59) OGTALDH1A1TP53ASAH1IDO1
SCHEMBL15788586 0.73 ALDH1A1 (0.64) OGTALDH1A1TP53IDO1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009086952-A2 COMPOSITIONS FOR THE TREATMENT OF DEGENERATIVE ARTICULAR DISEASES PROJECH SCIENCE TO TECHNOLOGY, S.L. (ES) 2009-07-16 WO claimed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285569-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF FRAGILE X Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
US-9645151-B2 Targeting phosphofructokinase and its glycosylation form for cancer CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-05-09 US disclosed
US-9645151-B2 Targeting phosphofructokinase and its glycosylation form for cancer CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-05-09 US disclosed
US-9573911-B2 Diphosphate mimetics and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-02-21 US disclosed
US-9573911-B2 Diphosphate mimetics and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-02-21 US disclosed
US-20150369809-A1 TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER CALIFORNIA INSTITUTE OF TECHNOLOGY 2015-12-24 US disclosed
US-20150369809-A1 TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER CALIFORNIA INSTITUTE OF TECHNOLOGY 2015-12-24 US disclosed
US-20140163079-A1 DIPHOSPHATE MIMETICS AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-06-12 US disclosed
US-20140163079-A1 DIPHOSPHATE MIMETICS AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-06-12 US disclosed
WO-2013006758-A1 DIPHOSPHATE MIMETICS AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-01-10 WO disclosed
US-20090325944-A1 Methods and Compositions for Modulating Glycosylation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2009-12-31 US disclosed
US-20090325944-A1 Methods and Compositions for Modulating Glycosylation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2009-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 OGT 3728/4885ALDH1A1 4306/4885TP53 3071/4885
US-20140163079-A1 DIPHOSPHATE MIMETICS AND USES THEREOF PLK1, OGA, MAPKAPK2 OGT 4/4885ALDH1A1 3317/4885TP53 1456/4885
US-20090325944-A1 Methods and Compositions for Modulating Glycosylation IAPP, OGA, IDE OGT 31/4885ALDH1A1 4021/4885TP53 2379/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 OGT 815/4885ALDH1A1 4642/4885TP53 1248/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 OGT 815/4885ALDH1A1 4642/4885TP53 1248/4885
US-20150369809-A1 TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER PFKFB1, PFKFB2, PGK1 OGT 44/4885ALDH1A1 895/4885TP53 95/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 OGT 3673/4885ALDH1A1 4788/4885TP53 3471/4885
US-20230285569-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF FRAGILE X CYFIP2, TPX2, CYFIP1 OGT 3760/4885ALDH1A1 4814/4885TP53 3984/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN OGT 1605/4885ALDH1A1 4687/4885TP53 2239/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF OGT 610/4885ALDH1A1 4592/4885TP53 1361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.