Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PGD | P52209 | 2/20 | 0.40 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478366 | 0.78 | CES2 (0.48) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| SCHEMBL27883402 | 0.71 | LMNA (0.47) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| SCHEMBL4036991 | 0.70 | PTPRA (0.56) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| SCHEMBL15511653 | 0.70 | CES2 (0.53) | GRM4CES2CES1SMN1; SMN2KMT2A | |
| SCHEMBL29915595 | 0.70 | ALDH1A1 (0.55) | GRM4CES2CES1KMT2ALMNA | |
| SCHEMBL7109048 | 0.70 | ALDH1A1 (0.55) | GRM4CES2CES1KMT2ALMNA | |
| SCHEMBL29096165 | 0.68 | CES2 (0.52) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| Potassium Ion SCHEMBL3752467 | 0.68 | CES2 (0.52) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| SCHEMBL11003297 | 0.68 | GSK3B (0.49) | GRM4CES2CES1EPHX2SMN1; SMN2 | |
| SCHEMBL18341350 | 0.68 | PGD (0.67) | PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056894-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-06-06 | — | — | US | claimed |
| EP-1370139-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2003-12-17 | — | — | EP | claimed |
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2002-09-19 | — | — | US | claimed |
| WO-2002059084-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2002-08-01 | — | — | WO | claimed |
| US-7504489-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2009-03-17 | — | — | US | disclosed |
| US-7056894-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-06-06 | — | — | US | disclosed |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2006-04-20 | — | — | US | disclosed |
| EP-1370139-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2003-12-17 | — | — | EP | disclosed |
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2002059084-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | GRM4 4844/4885CES2 631/4885CES1 473/4885 |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | GRM4 4844/4885CES2 668/4885CES1 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.