Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457676 | 0.80 | EGFR (0.59) | HPGDKDM4EPOLBCA1CA2 | |
| SCHEMBL23918989 | 0.79 | CA9 (0.47) | HPGDKDM4EFADS1CA1CA2 | |
| SCHEMBL4476657 | 0.77 | HPGD (0.55) | HPGDKDM4EFADS1POLBCA1 | |
| SCHEMBL26111565 | 0.75 | KCNH2 (0.47) | POLBKAT6ACCR2KCNH2PIK3CB | |
| SCHEMBL4196246 | 0.74 | CA1 (0.61) | HPGDKDM4EPOLBCA1CA2 | |
| SCHEMBL22097594 | 0.74 | KAT6A (0.39) | HPGDKDM4EPOLBKAT6AFLT1 | |
| SCHEMBL4196234 | 0.73 | KDM4E (0.68) | HPGDKDM4EPOLBCA1CA2 | |
| SCHEMBL8482825 | 0.73 | POLB (0.50) | POLBCA1CA2CA9KAT6A | |
| SCHEMBL4472201 | 0.72 | RAB9A (0.58) | POLBCA1CA2CA9AVPR2 | |
| SCHEMBL3160005 | 0.72 | GAA (0.72) | HPGDKDM4EFADS1POLBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |