Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | FLT4 | P35916 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196234 | 0.87 | KDM4E (0.68) | EGFRHPGDCA1CA2CA9 | |
| SCHEMBL4476657 | 0.84 | HPGD (0.55) | EGFRHPGDCA1CA2CA9 | |
| SCHEMBL4472196 | 0.80 | HPGD (0.47) | EGFRHPGDCA1CA2CA9 | |
| SCHEMBL28698398 | 0.78 | PTGS2 (0.71) | EGFRHPGDCA1CA2PTGS2 | |
| SCHEMBL23918989 | 0.78 | CA9 (0.47) | HPGDCA1CA2CA9PTGS1 | |
| SCHEMBL29022807 | 0.77 | LMNA (0.54) | HPGDCA1CA2CA9FLT1 | |
| SCHEMBL29963721 | 0.77 | LMNA (0.54) | HPGDCA1CA2CA9FLT1 | |
| SCHEMBL4477501 | 0.77 | KDM4E (0.47) | EGFRHPGDCA1CA2CA9 | |
| SCHEMBL4477897 | 0.75 | FLT1 (0.67) | FLT1FLT4KDRKAT6AKDM4E | |
| SCHEMBL10636104 | 0.75 | ALDH1A1 (0.49) | HPGDCA1CA2CA9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |