Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.50 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26111565 | 0.80 | KCNH2 (0.47) | POLB | |
| SCHEMBL4457678 | 0.79 | TP53 (0.73) | ACP1LMNATP53CYP2C9CA12 | |
| SCHEMBL17609451 | 0.79 | PTK2B (0.55) | LMNAAVPR2GPR27TP53POLB | |
| SCHEMBL4476659 | 0.75 | KMT2A (0.63) | SMN1; SMN2HTTACP1LMNATP53 | |
| SCHEMBL8482825 | 0.75 | POLB (0.50) | CA12CA1CA2CA9POLB | |
| SCHEMBL17609477 | 0.74 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2HTTLMNA | |
| SCHEMBL4196236 | 0.73 | LMNA (0.78) | SMN1; SMN2ACP1LMNATP53CYP2C9 | |
| SCHEMBL2303216 | 0.73 | LMNA (0.63) | SMN1; SMN2ACP1LMNATP53CYP2C9 | |
| SCHEMBL26112980 | 0.73 | KCNH2 (0.53) | GAAPOLB | |
| SCHEMBL6297162 | 0.73 | ACP1 (0.57) | RAB9ANPC1SMN1; SMN2HTTACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |