Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 5/20 | 0.38 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL78999 | 0.94 | DYRK1A (0.49) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL8470122 | 0.94 | DYRK1A (0.49) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL76053 | 0.88 | KDM4E (0.53) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL663745 | 0.88 | KDM4E (0.53) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL13516878 | 0.85 | KDM4E (0.44) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL1730016 | 0.85 | DYRK1A (0.42) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL8471715 | 0.85 | PNP (0.51) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL5372452 | 0.84 | KDM4E (0.51) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL15948930 | 0.83 | KDM4E (0.50) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Guanine SCHEMBL4007020 | 0.82 | ATAD2 (0.41) | DYRK1AKDM4EALDH1A1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118178636-A | Immunogenic compositions and uses thereof | 镁迪生医股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| US-20230102739-A1 | DETECTION OF EPIGENETIC MODIFICATIONS | CAMBRIDGE EPIGENETIX LIMITED (GB) | 2023-03-30 | — | — | US | claimed |
| EP-4013888-A1 | METHODS AND KITS FOR INFERTILITY DIAGNOSTICS | Washington State University (US) | 2022-06-22 | — | — | EP | claimed |
| CN-114599800-A | Method and kit for diagnosing infertility | 华盛顿州立大学 | 2022-06-07 | — | — | CN | claimed |
| WO-2021030725-A1 | METHODS AND KITS FOR INFERTILITY DIAGNOSTICS | WASHINGTON STATE UNIVERSITY (US) | 2021-02-18 | — | — | WO | claimed |
| US-10876163-B2 | Detection and quality control of regulatory T cells through DNA-methylation analysis of the Foxp3 gene | EPIONTIS GMBH (DE) | 2020-12-29 | — | — | US | claimed |
| CN-112022836-A | Preparation method of metal organic framework nano vaccine without refrigeration storage | 山东大学 | 2020-12-04 | — | — | CN | claimed |
| CN-110997935-A | Detection of epigenetic modifications | 剑桥表现遗传学有限公司 | 2020-04-10 | — | — | CN | claimed |
| EP-3625365-A2 | DETECTION OF EPIGENETIC MODIFICATIONS | Cambridge Epigenetix Limited (GB) | 2020-03-25 | — | — | EP | claimed |
| WO-2018211329-A2 | DETECTION OF EPIGENETIC MODIFICATIONS | CAMBRIDGE EPIGENETIX LIMITED (GB) | 2018-11-22 | — | — | WO | claimed |
| EP-2729127-B1 | METHODS FOR PRODUCING LIPOSOMES | STATENS SERUMINSTITUT (DK) | 2018-05-02 | — | — | EP | claimed |
| US-20140213475-A1 | METHODS OF DIAGNOSING CANCER USING EPIGENETIC BIOMARKERS | UNIVERSITY OF MASSACHUSETTS (US) | 2014-07-31 | — | — | US | claimed |
| EP-2729127-A2 | METHODS FOR PRODUCING LIPOSOMES | Statens Serum Institut (DK) | 2014-05-14 | — | — | EP | claimed |
| US-20140112979-A1 | METHODS FOR PRODUCING LIPOSOMES | STATENS SERUM INSTITUT (DK) | 2014-04-24 | — | — | US | claimed |
| WO-2013010181-A2 | METHODS OF DIAGNOSING CANCER USING EPIGENETIC BIOMARKERS | UNIVERSITY OF MASSACHUSETTS (US) | 2013-01-17 | — | — | WO | claimed |
| WO-2013004234-A2 | METHODS FOR PRODUCING LIPOSOMES | STATENS SERUM INSTITUT (DK) | 2013-01-10 | — | — | WO | claimed |
| US-20240210288-A1 | Representative Diagnostics | VENTANA MED SYST INC (US) | 2024-06-27 | — | — | US | disclosed |
| CN-118178636-A | Immunogenic compositions and uses thereof | 镁迪生医股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-2200638-A1 | A METHOD OF TRANSFECTION AND COMPOSITIONS THEREFOR | THE UNIVERSITY OF MELBOURNE (AU) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009046498-A1 | A METHOD OF TRANSFECTION AND COMPOSITIONS THEREFOR | THE UNIVERSITY OF MELBOURNE (AU) | 2009-04-16 | — | — | WO | disclosed |