SCHEMBL447683

SCHEMBL447683

CO[SiH2]c1cccc(C)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.41
ATM Q13315 1/20 0.41
CYP2A6 P11509 2/20 0.36
CYP1A2 P05177 1/20 0.36
MAPT P10636 1/20 0.35
TSHR P16473 2/20 0.35
ACHE P22303 1/20 0.35
ALDH1A1 P00352 5/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
TDP1 Q9NUW8 2/20 0.34
HTR1B P28222 1/20 0.33
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32
RAPGEF4 Q8WZA2 1/20 0.31
CD44 P16070 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5409861 0.86 TRPA1 (0.41) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL18315768 0.84 TRPA1 (0.39) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL7935157 0.83 TSHR (0.43) CYP2A6CYP1A2TSHRACHEALDH1A1
SCHEMBL1894227 0.82 TRPA1 (0.38) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL17865480 0.80 TRPA1 (0.37) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL4435873 0.79 TRPA1 (0.40) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL3841318 0.79 TRPA1 (0.35) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL2248050 0.79 TRPA1 (0.35) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL705275 0.79 TRPA1 (0.40) TRPA1ATMCYP2A6CYP1A2MAPT
SCHEMBL713415 0.79 TRPA1 (0.35) TRPA1ATMCYP2A6CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114456385-B Preparation method of MDT type methylphenyl silicone oil for cosmetics 湖南科技学院 2023-04-21 CN claimed
US-8784600-B2 Method for adhering glass THE YOKOHAMA RUBBER CO., LTD. (JP) 2014-07-22 US claimed
US-20120061020-A1 METHOD FOR ADHERING GLASS THE YOKOHAMA RUBBER CO., LTD. (JP) 2012-03-15 US claimed
CN-116234858-B Compositions and methods for reacting organosilicon compounds with silicon-based hydrides catalyzed by fluorinated arylborane Lewis acids 美国陶氏有机硅公司 2025-05-06 CN disclosed
CN-119317657-A Curable polyorganosiloxane compositions comprising phosphonium salts, methods of making and uses thereof 陶氏环球技术有限责任公司 2025-01-14 CN disclosed
CN-119100393-A Method for preparing high-purity nano silicon-carbon-oxygen ceramic powder by microwave induction graphite tube-array fluidized bed pyrolysis of silicon-carbon composite aerogel 绍兴晶彩科技有限公司 2024-12-10 CN disclosed
CN-119100394-A Method for preparing high-purity nano silicon carbide powder by combining microwave heating technology with self-suspension carbothermal reduction technology 绍兴晶彩科技有限公司 2024-12-10 CN disclosed
CN-118647675-A Thermally conductive composition and cured product thereof 信越化学工业株式会社 2024-09-13 CN disclosed
CN-114660896-B Composition for forming silicon-containing resist underlayer film, pattern forming method, and silicon compound 信越化学工业株式会社 2024-06-11 CN disclosed
EP-2589428-B1 SILICA FILM FILTER NGK INSULATORS LTD (JP) 2023-07-26 EP disclosed
CN-114456385-B Preparation method of MDT type methylphenyl silicone oil for cosmetics 湖南科技学院 2023-04-21 CN disclosed
US-8764889-B2 Silica film filter and process for producing silica film filter NGK INSULATORS, LTD. (JP) 2014-07-01 US disclosed
US-20130112078-A1 SILICA FILM FILTER AND PROCESS FOR PRODUCING SILICA FILM FILTER NGK INSULATORS, LTD. (JP) 2013-05-09 US disclosed
EP-2589428-A1 SILICA FILM FILTER AND PROCESS FOR PRODUCING SILICA FILM FILTER NGK Insulators, Ltd. (JP) 2013-05-08 EP disclosed
US-20130021546-A1 LIQUID-CRYSTAL DISPLAY ELEMENT AND SUBSTRATE USED IN SAME KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2013-01-24 US disclosed
US-8198016-B2 Patterning process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-06-12 US disclosed
US-20120061020-A1 METHOD FOR ADHERING GLASS THE YOKOHAMA RUBBER CO., LTD. (JP) 2012-03-15 US disclosed
US-20090286188-A1 Patterning process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2009-11-19 US disclosed
EP-0043640-B1 OPTICALLY CLEAR SILICONE COMPOSITIONS CURABLE TO ELASTOMERS DOW CORNING CORPORATION (US) 1985-10-16 EP disclosed
EP-0043640-A1 Optically clear silicone compositions curable to elastomers DOW CORNING CORPORATION (US) 1982-01-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130021546-A1 LIQUID-CRYSTAL DISPLAY ELEMENT AND SUBSTRATE USED IN SAME ZKSCAN2, L1CAM, SDC2 TRPA1 3729/4885ATM 3103/4885CYP2A6 4446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.