Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 7/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493386 | 0.87 | CTNNB1 (0.40) | CNR2CTNNB1WNT3ASMN1; SMN2LMNA | |
| SCHEMBL4485902 | 0.83 | MAOB (0.47) | CNR2SMN1; SMN2LMNAKMT2AKDM4E | |
| SCHEMBL16240695 | 0.78 | CTNNB1 (0.45) | CNR2CTNNB1WNT3ASMN1; SMN2LMNA | |
| SCHEMBL16252832 | 0.77 | CTNNB1 (0.44) | CNR2CTNNB1WNT3ASMN1; SMN2LMNA | |
| SCHEMBL6112119 | 0.76 | CTNNB1 (0.54) | CTNNB1WNT3AFASNKDM4ECYP2C19 | |
| SCHEMBL4492238 | 0.75 | NR1H2 (0.52) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6112218 | 0.74 | CTNNB1 (0.41) | CNR2CTNNB1WNT3ASMN1; SMN2LMNA | |
| SCHEMBL20674188 | 0.72 | KIF11 (0.46) | CTNNB1WNT3ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL6112279 | 0.71 | RBP4 (0.42) | CTNNB1WNT3ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL4480374 | 0.71 | ESR1 (0.56) | HSD17B1HSD17B2CNR2FASNP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | claimed |
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | HSD17B1 223/4885HSD17B2 328/4885CNR2 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.