Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493386 | 0.82 | CTNNB1 (0.40) | NR1H2NR1H3MAOBALDH1A1HTT | |
| SCHEMBL4484338 | 0.75 | NR1H2 (0.50) | NR1H2NR1H3SRD5A2NR4A2NR4A1 | |
| SCHEMBL4479259 | 0.75 | HSD17B1 (0.43) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4485902 | 0.74 | MAOB (0.47) | MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL4492330 | 0.73 | NR1H2 (0.46) | NR1H2NR1H3SRD5A2NR4A2NR4A1 | |
| SCHEMBL3232949 | 0.71 | SRD5A2 (0.90) | SRD5A2NR4A2NR4A1NR4A3PLA2G4B | |
| SCHEMBL1408097 | 0.71 | NR1H2 (0.59) | NR1H2NR1H3RXRARXRBRXRG | |
| SCHEMBL16252832 | 0.70 | CTNNB1 (0.44) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7764407 | 0.70 | NR4A2 (0.68) | SRD5A2NR4A2NR4A1NR4A3PLA2G4B | |
| SCHEMBL402300 | 0.69 | SRD5A2 (0.87) | SRD5A2NR4A2NR4A1NR4A3PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522884-B2 | Compositions and methods for the treatment of metabolic disorders | CELLIX BIO PRIVATE LIMITED (IN) | 2016-12-20 | — | — | US | disclosed |
| US-20150141468-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS | MAHESH KANDULA (IN) | 2015-05-21 | — | — | US | disclosed |
| WO-2013167991-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS | KANDULA MAHESH (IN) | 2013-11-14 | — | — | WO | disclosed |
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2006066806-A1 | MANUFACTURE OF VITAMIN B6 | DSM IP ASSETS B.V. (NL) | 2006-06-29 | — | — | WO | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141468-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS | GLS, SI, FPGS | NR1H2 56/4885NR1H3 58/4885SRD5A2 153/4885 |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | NR1H2 572/4885NR1H3 606/4885SRD5A2 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.