Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 4/20 | 0.49 |
| ▸ | ACE | P12821 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620971 | 0.79 | NR1D1 (0.47) | NR1D1ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL4480030 | 0.74 | NR1D1 (0.61) | NR1D1ACEBCL2BAD | |
| SCHEMBL29409306 | 0.74 | NR1D1 (0.61) | NR1D1ACEBCL2BAD | |
| SCHEMBL6650752 | 0.74 | NR1D1 (0.61) | NR1D1ACEBCL2BAD | |
| SCHEMBL28556786 | 0.74 | NR1D1 (0.68) | NR1D1ACEPOLBBCL2BAD | |
| SCHEMBL29409301 | 0.74 | NR1D1 (0.68) | NR1D1ACEPOLBBCL2BAD | |
| SCHEMBL29727828 | 0.74 | NPSR1 (0.53) | NR1D1NPSR1 | |
| SCHEMBL8233145 | 0.74 | NPSR1 (0.53) | NR1D1NPSR1 | |
| SCHEMBL4573235 | 0.74 | ACE (0.61) | ACEPOLBTDP1L3MBTL1CHEK1 | |
| SCHEMBL8908771 | 0.74 | ACE (0.61) | ACEPOLBTDP1L3MBTL1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | NR1D1 3551/4885ACE 1718/4885POLB 3098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.