SCHEMBL448018

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL30795090	1.00	LMNA (0.40)	LMNACYP1A2CYP2C19CYP2C9MCL1
	SCHEMBL448016	0.89	ALDH1A1 (0.41)	ALDH1A1ACLYPOLBCXCR2PDK1
	SCHEMBL449207	0.89	MCL1 (0.43)	LMNACYP1A2CYP2C19CYP2C9MCL1
	SCHEMBL30794636	0.89	MCL1 (0.43)	LMNACYP1A2CYP2C19CYP2C9MCL1
	SCHEMBL448838	0.86	CYP2C9 (0.39)	LMNACYP1A2CYP2C19CYP2C9CYP3A4
	SCHEMBL30795166	0.86	CYP2C9 (0.39)	LMNACYP1A2CYP2C19CYP2C9CYP3A4
	SCHEMBL30794605	0.79	ALDH1A1 (0.42)	LMNACYP1A2CYP2C19CYP2C9ALDH1A1
	SCHEMBL451705	0.79	ALDH1A1 (0.42)	LMNACYP1A2CYP2C19CYP2C9ALDH1A1
	SCHEMBL449648	0.79	PTGS2 (0.49)	LMNACYP1A2CYP2C9CYP3A4GAA
	SCHEMBL30795150	0.79	PTGS2 (0.49)	LMNACYP1A2CYP2C9CYP3A4GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.