Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 3/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 3/20 | 0.36 |
| ▸ | PGK2 | P07205 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL9559766 | 0.96 | ACP3 (0.44) | ACP3PTPN5ESR1ESR2MMP8 | |
| Benzidine SCHEMBL7598479 | 0.84 | ALDH1A1 (0.65) | CA14CA2LMNATSHR | |
| Biphenyl SCHEMBL1945860 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL3727875 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL342228 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL263925 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL27485598 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL3763955 | 0.82 | ALDH1A1 (0.60) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL19244130 | 0.79 | ALDH1A1 (0.56) | ACP3PTPN5MMP8MMP14CA14 | |
| Biphenyl SCHEMBL356478 | 0.79 | ALDH1A1 (0.56) | ACP3PTPN5MMP8MMP14CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110845905-A | Paint remover and production method thereof | 嘉纳尔科技（北京）有限公司 | 2020-02-28 | — | — | CN | claimed |
| CN-110662752-B | Bcl family antagonist phosphoheterocyclic compounds for the clinical management of conditions caused or mediated by senescent cells and the treatment of cancer | 尤尼蒂生物技术公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-110662752-A | Bcl family antagonist phosphoheterocyclic compounds for the clinical management of conditions caused or mediated by senescent cells and the treatment of cancer | 尤尼蒂生物技术公司 | 2020-01-07 | — | — | CN | disclosed |
| US-8491900-B2 | Antibodies to signal transduction protein TAB2 | MATSUMOTO KUNIHIRO (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20120064084-A1 | SIGNAL TRANSDUCTION PROTEIN TAB2 | MATSUMOTO KUNIHIRO (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8105799-B2 | Using transforming growth factor-beta -activated kinase-1 (TAK-1) and TAK1 binding protein 1(TAB-1) as evaluative tool in detection of modulators of interleukin and tumor necrosis factor activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-01-31 | — | — | US | disclosed |
| US-8058241-B2 | Signal transduction protein TAB2 | MATSUMOTO KUNIHIRO (JP) | 2011-11-15 | — | — | US | disclosed |
| EP-1234880-B9 | NOVEL PROTEIN TAB2 | MATSUMOTO KUNIHIRO (JP) | 2009-09-23 | — | — | EP | disclosed |
| EP-1127944-B9 | METHODS FOR SCREENING COMPOUNDS INHIBITING INFLAMMATORY CYTOKINE PRODUCTION | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-08-12 | — | — | EP | disclosed |
| EP-1127944-B1 | METHODS FOR SCREENING COMPOUNDS INHIBITING INFLAMMATORY CYTOKINE PRODUCTION | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-02-04 | — | — | EP | disclosed |
| US-7153664-B2 | Signal transduction protein TAB2 | MATSUMOTO KUNIHIRO | 2006-12-26 | — | — | US | disclosed |
| EP-1243923-B1 | METHOD OF SCREENING REMEDY FOR CANCER WITH THE USE OF INTERACTION DOMAINS OF p53 AND MORTALIN | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2006-03-08 | — | — | EP | disclosed |
| US-20060040316-A1 | Method for screening compounds inhibiting signal transduction through inflammatory cytokines | CHUGAI SEIYAKU KABUSHIKI KAISHA, (JP) | 2006-02-23 | — | — | US | disclosed |
| US-6989244-B1 | Method for screening compounds inhibiting signal transduction through inflammatory cytokines | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-01-24 | — | — | US | disclosed |
| EP-1557670-A1 | REGULATION OF INTERACTION BETWEEN RAPL AND Rap1 | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2005-07-27 | — | — | EP | disclosed |
| US-20030087263-A1 | Method of screening remedy for cancer with the use of interaction domain of p53 and mortalin | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-05-08 | — | — | US | disclosed |
| US-20030040050-A1 | Novel protein TAB2 | MATSUMOTO KUNIHIRO (JP) | 2003-02-27 | — | — | US | disclosed |
| EP-1243923-A1 | METHOD OF SCREENING REMEDY FOR CANCER WITH THE USE OF INTERACTION DOMAINS OF p53 AND MORTALIN | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
| EP-1234880-A1 | NOVEL PROTEIN TAB2 | Matsumoto, Kunihiro (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-1127944-A1 | METHOD FOR SCREENING COMPOUND INHIBITING SIGNAL TRANSDUCTION OF INFLAMMATORY CYTOKINE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-08-29 | — | — | EP | disclosed |