Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569156 | 0.84 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2DPP4TSHRPOLB | |
| SCHEMBL729426 | 0.83 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 | |
| SCHEMBL569861 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 | |
| SCHEMBL3652188 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 | |
| SCHEMBL11668092 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2DPP4POLBMAPT | |
| SCHEMBL4426785 | 0.78 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 | |
| Hydrochloric Acid SCHEMBL27529568 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 | |
| SCHEMBL9456466 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2DPP4POLBMAPT | |
| SCHEMBL16240025 | 0.76 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2DPP4GRIN2DGRIN3B | |
| SCHEMBL7596175 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2DPP4TSHRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501407-B2 | Pyrimidine A2B selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-6916804-B2 | Pyrimidine A2b selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-20050119271-A1 | Pyrimidine A2B selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. | 2005-06-02 | — | — | US | disclosed |
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
| US-5463007-A | Aqueous, rapid curing, emulsion of vinyl acetate, vinyl acetate, ethylene, and an acrylamidobutyraldehyde acetal; coatings, binders, adhesives; waterproofing, adhesion, solvent resistance | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1995-10-31 | — | — | US | disclosed |
| WO-1990015825-A1 | RELATIVELY SOFT PLIABLE WATER-SWELLABLE POLYMER | WEYERHAEUSER COMPANY (US) | 1990-12-27 | — | — | WO | disclosed |
| WO-1990015830-A1 | HYDROCOLLOID POLYMER | WEYERHAEUSER COMPANY (US) | 1990-12-27 | — | — | WO | disclosed |
| US-4663410-A | Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0218827-A2 | Polymers of self- and diol reactive formaldehyde-free crosslinking monomers | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1987-04-22 | — | — | EP | disclosed |
| EP-0211432-A2 | Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1987-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119271-A1 | Pyrimidine A2B selective antagonist compounds, their synthesis and use | ADORA2B, ADORA2A, ADORA3 | ALDH1A1 2146/4885SMN1; SMN2 2019/4885DPP4 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.