Sugi Predict

Sugi Predict / Compounds / SCHEMBL448536

SCHEMBL448536

SCHEMBL448536

COC(C)Nc1ccc(N)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR4A1 P22736 1/20 0.45
▸ TDP1 Q9NUW8 7/20 0.39
▸ MAPK1 P28482 2/20 0.39
▸ ALDH1A1 P00352 6/20 0.39
▸ MAPT P10636 5/20 0.39
▸ L3MBTL1 Q9Y468 4/20 0.39
▸ CYP3A4 P08684 4/20 0.38
▸ ALOX15 P16050 3/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ HSD17B10 Q99714 3/20 0.37
▸ THRB P10828 2/20 0.37
▸ TSHR P16473 2/20 0.37
▸ ALOX12 P18054 2/20 0.37
▸ TP53 P04637 2/20 0.37
▸ HSP90AA1 P07900 1/20 0.37
▸ CASP1 P29466 1/20 0.37
▸ HIF1A Q16665 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734438 0.89 ALDH1A1 (0.44) TDP1MAPK1ALDH1A1MAPTL3MBTL1
SCHEMBL4454171 0.78 TDP1 (0.42) NR4A1TDP1MAPK1ALDH1A1MAPT
SCHEMBL4621245 0.77 TDP1 (0.58) TDP1MAPK1ALDH1A1MAPTL3MBTL1
SCHEMBL475453 0.77 TDP1 (0.56) NR4A1TDP1MAPK1ALDH1A1MAPT
SCHEMBL28349412 0.77 TDP1 (0.42) NR4A1TDP1MAPK1ALDH1A1MAPT
SCHEMBL8995968 0.75 ALDH1A1 (0.46) TDP1MAPK1ALDH1A1MAPTCYP3A4
SCHEMBL8431367 0.75 TDP1 (0.54) NR4A1TDP1MAPK1ALDH1A1MAPT
Hydrogen Sulfide SCHEMBL8431365 0.75 TDP1 (0.54) NR4A1TDP1MAPK1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL10534023 0.75 TDP1 (0.54) NR4A1TDP1ALDH1A1MAPTL3MBTL1
SCHEMBL4951647 0.74 ALDH1A1 (0.47) NR4A1TDP1MAPK1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 472 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118043024-A Solid composition for dyeing keratin 花王株式会社 2024-05-14 — — CN claimed
US-10639257-B2 Composition for colouring keratin fibres BEAUTY & BUSINESS S.P.A. (IT) 2020-05-05 — — US claimed
EP-3638200-A1 PROCESS FOR DYEING KERATIN MATERIALS USING AT LEAST ONE BLUE, PURPLE OR GREEN DYE AND AT LEAST ONE DISULFIDE, THIOL OR PROTECTED THIOL FLUORESCENT DYE L'Oreal (FR) 2020-04-22 — — EP claimed
US-20190117541-A1 COMPOSITION FOR COLOURING KERATIN FIBRES BEAUTY & BUSINESS S.P.A. (IT) 2019-04-25 — — US claimed
EP-2658507-B1 OXIDATIVE COLOURING COMPOSITION KAO GERMANY GMBH (DE) 2019-04-24 — — EP claimed
WO-2018229296-A1 PROCESS FOR DYEING KERATIN MATERIALS USING AT LEAST ONE BLUE, PURPLE OR GREEN DYE AND AT LEAST ONE DISULFIDE, THIOL OR PROTECTED THIOL FLUORESCENT DYE L'OREAL (FR) 2018-12-20 — — WO claimed
CN-108670871-A A kind of hair dye and its application method 花安堂生物科技集团有限公司 2018-10-19 — — CN claimed
US-8465552-B2 Thickened hair colors ISP INVESTMENTS, INC. (US) 2013-06-18 — — US claimed
CN-101229106-B Dye composition of acidic ph comprising 2,3-diamino-6,7-dihydro-1h,5h-pyrazolo[1,2-a]pyrazol-1-one, a para- phenylenediamine, a meta-aminophenol and an oxidizing agent OREAL 2013-04-10 — — CN claimed
US-20120317734-A1 THICKENED HAIR COLORS ISP INVESTMENTS INC. (US) 2012-12-20 — — US claimed
US-5948121-A PERMANENT DYEING OF KERATINOUS FIBERS. LACCASE DERIVED FROM A STRAIN OF THE GENUS MYCELIOPHTHORA NOVO NORDISK A/S (DK) 1999-09-07 — — US claimed
EP-0819423-B1 Composition for the oxydative dyeing of keratinic fibers and dyeing process applying them OREAL (FR) 1998-12-16 — — EP claimed
US-5752983-A Composition for oxidation dyeing of keratinous fibres comprising an oxidation base, a coupler, and 4-hydroxyindole as coupler and dyeing process with this composition L'OREAL (FR) 1998-05-19 — — US claimed
EP-0416962-B1 KERATINOUS FIBERS DYEING PROCESS WITH INDOLE DYES AND OXIDATION DYE PRECURSORS AND DYEING AGENTS L'OREAL (FR) 1993-09-22 — — EP claimed
EP-0370880-B1 TRIALKOXY-SUBSTITUTED M-PHENYLENE DIAMINES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS COUPLING AGENTS IN THE OXIDATION DYEING OF KERATINIC FIBRES, ESPECIALLY HUMAN HAIR L'OREAL (FR) 1992-11-11 — — EP claimed
EP-0295474-B1 CHLOROMETAPHENYLENEDIAMINES, THEIR USE AS COUPLING AGENTS IN OXYDATION COLOURING OF KERATINIC FIBRES, COLOURITY COMPOSITIONS FOR HAIR CONTAINING THESE COMPOUNDS AND COLOURING PROCESS USING THESE COMPOSITIONS L'OREAL (FR) 1991-07-17 — — EP claimed
EP-0294669-B1 METAPHENYLENDIAMINES, PROCESS FOR THEIR PREPARATION, INTERMEDIATE COMPOUNDS AND USE OF THESE METAPHENYLENDIAMINES AS COUPLERS IN OXYDATIVE COLOURING OF KERATINIC FIBRES ESPECIALLY OF HUMAN HAIR L'OREAL (FR) 1991-07-17 — — EP claimed
EP-0370880-A1 Trialkoxy-substituted m-phenylene diamines, process for their preparation, and their use as coupling agents in the oxidation dyeing of keratinic fibres, especially human hair L'OREAL (FR) 1990-05-30 — — EP claimed
US-4904275-A OXIDIZER L'OREAL (FR) 1990-02-27 — — US claimed
US-4891045-A DYEING HAIR L'OREAL (FR) 1990-01-02 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120317734-A1 THICKENED HAIR COLORS KRT18, PLOD3, PLOD1 NR4A1 3573/4885TDP1 3128/4885MAPK1 4059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.