Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28970061 | 0.86 | ALDH1A1 (0.71) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Quinoline SCHEMBL372690 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5283313 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5874493 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Cadaverine Tartrate SCHEMBL5874249 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPSR1RXFP1 | |
| Quinoline SCHEMBL5874640 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPSR1RXFP1 | |
| Cadaverine Tartrate SCHEMBL5874237 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPSR1RXFP1 | |
| Cadaverine Tartrate SCHEMBL28081412 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPSR1RXFP1 | |
| Quinoline SCHEMBL5272119 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Quinoline SCHEMBL2201840 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511065-B2 | Mixed lineage kinase modulators | ELI LILLY AND COMPANY (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | ELI LILLY AND COMPANY | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | MYLK2, CSNK1G2, CSNK1A1 | ALDH1A1 3779/4885PABPC1 1949/4885KDM4E 2001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.