Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL5283313 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL5874493 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL372690 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL4485979 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Cadaverine Tartrate SCHEMBL5874237 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Cadaverine Tartrate SCHEMBL28081412 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Cadaverine Tartrate SCHEMBL5874249 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL28116721 | 0.84 | ALDH1A1 (0.57) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL2201840 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1KDM4ENPC1MEN1 | |
| Quinoline SCHEMBL5272119 | 0.84 | ALDH1A1 (0.74) | ALDH1A1PABPC1KDM4ENPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |