Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL28081412 | 1.00 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| Cadaverine Tartrate SCHEMBL5874237 | 1.00 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| Quinoline SCHEMBL27820159 | 0.87 | ALDH1A1 (0.61) | ALDH1A1CYP1A2PABPC1KDM4EMEN1 | |
| Quinoline SCHEMBL372690 | 0.86 | ALDH1A1 (0.77) | ALDH1A1CYP1A2CYP2C19PABPC1KDM4E | |
| Quinoline SCHEMBL5874493 | 0.86 | ALDH1A1 (0.77) | ALDH1A1CYP1A2CYP2C19PABPC1KDM4E | |
| Quinoline SCHEMBL5283313 | 0.86 | ALDH1A1 (0.77) | ALDH1A1CYP1A2CYP2C19PABPC1KDM4E | |
| Quinoline SCHEMBL4485979 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5874640 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PABPC1KDM4EMEN1KMT2A | |
| Gluconic Acid SCHEMBL6753103 | 0.85 | PDE4A (0.54) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| Cadaverine Tartrate SCHEMBL3454249 | 0.84 | KDM4E (0.44) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079383-A4 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION. | US SECRETARY UNITED STATES DEP (US) | 1984-01-12 | — | — | EP | claimed |
| EP-0079383-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1983-05-25 | — | — | EP | claimed |
| WO-1982004049-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | US HEALTH (US) | 1982-11-25 | — | — | WO | claimed |
| CN-107522766-A | One kind has ursolic acid quinolyl hydrazide derivatives of antitumor activity and its preparation method and application | 南京林业大学 | 2017-12-29 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-5783205-A | HEATING A BIOERODIBLE OLIGOMER OR POLYMER CONTAINING DRUG AND INTRODUCING IT INTO A DISEASED TISSUE POCKET, SUCH AS A PERIODONTAL POCKET | ALZA CORPORATION (US) | 1998-07-21 | — | — | US | disclosed |
| US-5620700-A | INJECTING MELT OF DRUG-CONTAINING OLIGOMER OR POLYMER MATRIX INTO PERIODONTAL POCKET, COOLING TO BODY TEMPERATURE TO HARDEN | ALZA CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| WO-1992007555-A1 | DRUG DELIVERY SYSTEM AND METHOD | ALZA CORPORATION (US) | 1992-05-14 | — | — | WO | disclosed |
| CN-85105798-A | Octahydro- azoles is the preparation method of [4,5-g] quinoline also | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85101547-A | The preparation method and its usage of novel octahydro thiazole [4,5-g] and quinoline compound | — | 1987-01-24 | — | — | CN | disclosed |