Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478644 | 0.82 | KDM4E (0.39) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4345873 | 0.81 | HSD11B1 (0.44) | CRHR1NPC1ALDH1A1LMNARAB9A | |
| SCHEMBL22599742 | 0.79 | PDE2A (0.34) | NPC1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4349748 | 0.76 | ALDH1A1 (0.47) | POLBNPC1ALDH1A1LMNARAB9A | |
| SCHEMBL27007893 | 0.75 | HSD11B1 (0.47) | MAPK14CRHR1POLB | |
| SCHEMBL19328339 | 0.74 | KMT2A (0.45) | NPC1ALDH1A1RAB9A | |
| SCHEMBL10012799 | 0.71 | HSD11B1 (0.46) | NPC1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL25412393 | 0.70 | LMNA (0.38) | NPC1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL25413578 | 0.70 | ALDH1A1 (0.36) | POLBNPC1ALDH1A1LMNARAB9A | |
| SCHEMBL2945910 | 0.70 | S100A4 (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |