Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.36 |
| ▸ | ESR1 | P03372 | 8/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492063 | 0.62 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL2477255 | 0.59 | ESR1 (0.74) | ESR1ESR2 | |
| SCHEMBL11523292 | 0.57 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL20032315 | 0.57 | CYP3A4 (0.42) | — | |
| SCHEMBL5168001 | 0.56 | ESR1 (0.43) | PTGS1ESR1ESR2 | |
| SCHEMBL984070 | 0.56 | ESR1 (0.72) | PTGS1ESR1ESR2 | |
| SCHEMBL15688276 | 0.55 | ESR1 (0.47) | PTGS1PTGS2ESR1ESR2 | |
| SCHEMBL27744547 | 0.55 | ESR1 (0.56) | PTGS1PTGS2ESR1ESR2 | |
| SCHEMBL2383072 | 0.54 | HIF1A (0.53) | ESR1ESR2 | |
| SCHEMBL22354939 | 0.54 | ESR1 (0.55) | PTGS1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281120-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ONO PHARMACEUTICAL CO., LTD (JP) | 2009-11-12 | — | — | US | disclosed |
| EP-1961745-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281120-A1 | BICYCLIC HETEROCYCLIC COMPOUND | CRHR1, NR3C1, CNR1 | PTGS1 2000/4885PTGS2 2499/4885CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.