Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492136 | 1.00 | MTNR1A (0.38) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4510087 | 1.00 | MTNR1A (0.38) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL3280740 | 0.87 | MTNR1A (0.38) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4499068 | 0.85 | MTNR1A (0.37) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4499073 | 0.85 | MTNR1A (0.37) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL3280705 | 0.84 | MTNR1A (0.38) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4504558 | 0.84 | MLKL (0.41) | CYP19A1KDM4EHSD17B10TP53MAPT | |
| SCHEMBL4504554 | 0.84 | MLKL (0.41) | CYP19A1KDM4EHSD17B10TP53MAPT | |
| SCHEMBL8203579 | 0.83 | MTNR1A (0.38) | MTNR1AMTNR1BCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4492579 | 0.82 | MTNR1A (0.48) | MTNR1AMTNR1BCYP19A1KDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612099-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1957483-A1 | NOVEL VINYLOGOUS ACIDS DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007063010-A1 | NOVEL VINYLOGOUS ACIDS DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070129421-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129421-A1 | Vinylogous acid derivatives | CMA1, TPSG1, TPSAB1 | MTNR1A 454/4885MTNR1B 756/4885CYP19A1 1030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.