Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.68 |
| ▸ | METAP1 | P53582 | 2/20 | 0.64 |
| ▸ | METAP2 | P50579 | 1/20 | 0.64 |
| ▸ | CBFB | Q13951 | 1/20 | 0.64 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | GUSB | P08236 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946648 | 0.93 | NPC1 (0.70) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL3341622 | 0.89 | GUSB (0.65) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL12145570 | 0.89 | AMY1A (0.59) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL7398247 | 0.89 | AMY1A (0.71) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL12072142 | 0.89 | NPC1 (0.71) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL13203529 | 0.87 | NPC1 (0.61) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL1170803 | 0.84 | FABP6 (0.63) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL30038044 | 0.84 | FABP6 (0.63) | NPC1RAB9AATMERAP1METAP1 | |
| SCHEMBL3337332 | 0.84 | METAP2 (0.62) | NPC1RAB9AMETAP1METAP2CBFB | |
| SCHEMBL21111643 | 0.83 | RAB9A (0.68) | NPC1RAB9AATMERAP1METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-7132439-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | NPC1 1216/4885RAB9A 3054/4885ATM 4022/4885 |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | NPC1 1216/4885RAB9A 3054/4885ATM 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.