Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.71 |
| ▸ | RAB9A | P51151 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.56 |
| ▸ | CBFB | Q13951 | 1/20 | 0.56 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494716 | 0.89 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2946648 | 0.85 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2250359 | 0.83 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2681611 | 0.83 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7398247 | 0.81 | AMY1A (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3341622 | 0.81 | GUSB (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12145570 | 0.81 | AMY1A (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12072293 | 0.81 | AMY1A (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28081555 | 0.80 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11284879 | 0.79 | GAA (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2021-09-14 | — | — | US | disclosed |
| US-10629817-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2020-04-21 | — | — | US | disclosed |
| US-10224493-B2 | Boron-containing compounds | MERCK PATENT GMBH (DE) | 2019-03-05 | — | — | US | disclosed |
| US-20180145260-A1 | MATERIALS FOR ORGANIC ELECTRLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| EP-2906575-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2018-01-17 | — | — | EP | disclosed |
| US-9831446-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9831446-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-11-28 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20150270500-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-09-24 | — | — | US | disclosed |
| US-20150270500-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-09-24 | — | — | US | disclosed |
| WO-2014056564-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | WO | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| WO-2011157339-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180145260-A1 | MATERIALS FOR ORGANIC ELECTRLUMINESCENT DEVICES | KCNB2, KCNB1, GJB2 | NPC1 1470/4885RAB9A 2637/4885SMN1; SMN2 3491/4885 |
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | PORCN, COASY, AAAS | NPC1 3971/4885RAB9A 1790/4885SMN1; SMN2 3569/4885 |
| US-20130082209-A1 | METAL COMPLEXES | MCOLN2, MCOLN1, AP1M1 | NPC1 1682/4885RAB9A 1404/4885SMN1; SMN2 1996/4885 |
| US-20150270500-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | NPC1 3516/4885RAB9A 2201/4885SMN1; SMN2 3736/4885 |
| US-10224493-B2 | Boron-containing compounds | BRI3BP, BTD, BICRA | NPC1 1374/4885RAB9A 1514/4885SMN1; SMN2 3497/4885 |
| US-10629817-B2 | Materials for organic electroluminescent devices | KCNB2, KCNB1, GJB2 | NPC1 1578/4885RAB9A 2413/4885SMN1; SMN2 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.