SCHEMBL44954

SCHEMBL44954

COC(C)(C)c1cccc(C(C)(C)OC)c1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
ALDH1A1 P00352 1/20 0.41
ALOX15 P16050 1/20 0.41
PGK1 P00558 2/20 0.37
PGK2 P07205 2/20 0.37
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HSD17B10 Q99714 1/20 0.33
CES1 P23141 1/20 0.33
KIF11 P52732 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
KCNN4 O15554 1/20 0.32
GAA P10253 1/20 0.32
ACHE P22303 3/20 0.31
TAAR1 Q96RJ0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12500725 0.93 HDAC8 (0.44) MAPK1ESR1ESR2ALDH1A1ALOX15
SCHEMBL4188953 0.88 KIF11 (0.47) MAPK1ALDH1A1ALOX15KIF11
SCHEMBL12032158 0.86 ACHE (0.46) MAPK1ALDH1A1ALOX15KIF11ACHE
SCHEMBL14650861 0.84 ALDH1A1 (0.46) MAPK1ALDH1A1ALOX15KIF11GAA
SCHEMBL45192 0.83 HSD17B10 (0.38) MAPK1ALDH1A1ALOX15HSD17B10
SCHEMBL42639 0.81 MAPK1 (0.67) MAPK1ESR1ESR2ALDH1A1ALOX15
SCHEMBL12500683 0.81 HDAC4 (0.44) MAPK1ALDH1A1ALOX15HDAC4HDAC2
SCHEMBL19255653 0.80 MAPK1 (0.52) MAPK1ESR1ESR2ALDH1A1ALOX15
SCHEMBL14520982 0.80 KIF11 (0.42) KIF11
SCHEMBL12192497 0.80 TP53 (0.47) MAPK1ALDH1A1ALOX15HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8063154-B2 Preparation of exo-olefin terminated polyolefins via quenching with alkoxysilanes or ethers THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2011-11-22 US claimed
US-8013073-B2 Method for preparing polyolefins containing vinylidine end groups using nonaromatic heterocyclic compounds CHEVRON ORONITE COMPANY LLC (US) 2011-09-06 US claimed
US-7816459-B2 Method for preparing polyolefins containing vinylidine end groups using polymeric nitrogen compounds CHEVRON ORONITE COMPANY LLC (US) 2010-10-19 US claimed
EP-1803751-B1 Method for preparing polyolefins containing vinylidene end groups using polymeric nitrogen compounds CHEVRON ORONITE CO (US) 2010-06-30 EP claimed
EP-1803748-B1 Method for preparing polyolefins containing vinylidene end groups using nonaromatic heterocyclic compounds CHEVRON ORONITE CO (US) 2010-06-09 EP claimed
US-20090318624-A1 Preparation of exo-olefin terminated polyolefins via quenching with alkoxysilanes or ethers UNIVERSITY OF SOUTHERN MISSISSIPPI 2009-12-24 US claimed
US-20090247716-A1 Production of Vinylidene-Terminated Polyolefins Via Quenching with Monosulfides CHEVRON ORONITE COMPANY LLC 2009-10-01 US claimed
EP-1803741-B1 Method for preparing polyolefins containing vinylidene groups using azole compounds CHEVRON ORONITE CO (US) 2009-01-21 EP claimed
US-20070155911-A1 Method for preparing polyolefins containing vinylidine end groups using nonaromatic heterocyclic compounds UNIVERSITY OF SOUTHERN MISSISSIPPI 2007-07-05 US claimed
US-20070155910-A1 Method for preparing polyolefins containing vinylidine end groups using polymeric nitrogen compounds CHEVRON ORONITE COMPANY LLC 2007-07-05 US claimed
US-20070155908-A1 contacting a olefin monomer (isobutylene) with an initiator( 2-chloro-2,4,4,-trimethylpentane) in the presence of a Lewis acid and solvent under suitable quasiliving polymerization reaction conditions, contacting quasiliving carbocationically terminated polymer with an oxazole or thiazoles quencher CHEVRON ORONITE COMPANY LLC 2007-07-05 US claimed
EP-1803751-A1 Method for preparing polyolefins containing vinylidene end groups using polymeric nitrogen compounds Chevron Oronite Company LLC (US) 2007-07-04 EP claimed
EP-1803748-A1 Method for preparing polyolefins containing vinylidene end groups using nonaromatic heterocyclic compounds Chevron Oronite Company LLC (US) 2007-07-04 EP claimed
EP-1803741-A1 Method for preparing polyolefins containing vinylidene groups using azole compounds Chevron Oronite Company LLC (US) 2007-07-04 EP claimed
US-11795247-B2 Polyolefin dispersants and methods of making and using thereof THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2023-10-24 US disclosed
US-11548974-B2 Modified polyisobutylene-based polymers, methods of making, and medical devices MEDTRONIC, INC. (US) 2023-01-10 US disclosed
US-11274181-B2 Polyimide dispersants and methods of making and using thereof CHEVRON ORONITE COMPANY LLC (US) 2022-03-15 US disclosed
US-20090258803-A1 COPOLYMERS MADE WITH QUASI-LIVING POLYOLEFINS AND UNSATURATED ACIDIC REAGENTS, DISPERSANTS USING SAME, AND METHODS OF MAKING SAME CHEVRON ORONITE COMPANY, LLC 2009-10-15 US disclosed
US-20090247716-A1 Production of Vinylidene-Terminated Polyolefins Via Quenching with Monosulfides CHEVRON ORONITE COMPANY LLC 2009-10-01 US disclosed
WO-2008118576-A1 POLYDISPERSITY-CONTROLLED ISOOLEFIN POLYMERIZATION WITH POLYMORPHOGENATES EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-10-02 WO disclosed