Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | PRF1 | P14222 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29838115 | 1.00 | MAOA (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4455687 | 0.75 | KDM4E (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL855947 | 0.75 | MAOB (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1611599 | 0.75 | MAOA (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL32672790 | 0.75 | TDP2 (0.50) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL31616856 | 0.75 | KDM4E (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL855553 | 0.75 | MAOA (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL854978 | 0.75 | MAOA (0.47) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7001855 | 0.75 | MAPT (0.53) | MAOAMAOBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL26898428 | 0.75 | KDM4E (0.44) | MAOAMAOBALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. | 2004-08-12 | — | — | US | claimed |
| EP-1390339-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | Syngenta Participations AG (CH) | 2004-02-25 | — | — | EP | claimed |
| WO-2002094760-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-11-28 | — | — | WO | claimed |
| CN-112142702-B | Synthesis method of 7-mercapto-isobenzofuran-1 (3H) -ketone compound | 烟台药物研究所 | 2022-07-29 | — | — | CN | disclosed |
| CN-112142702-A | Synthesis method of 7-mercapto-isobenzofuran-1 (3H) -ketone compound | 烟台药物研究所 | 2020-12-29 | — | — | CN | disclosed |
| US-7528266-B2 | Chemical intermediates of byproduct-free 7-thio-3H-isobenzofuran-1-one derivatives and herbicidal 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methyl-3H-isobenzo-furan-1-one | SYNGENTA CROP PROTECTION, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7307175-B2 | Process for the preparation of 7-substituted 3-alkyl-3H-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1390339-B1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-02-01 | — | — | EP | disclosed |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. | 2004-08-12 | — | — | US | disclosed |
| EP-1390339-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | Syngenta Participations AG (CH) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002094760-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, CYP2S1, SULT2A1 | MAOA 1923/4885MAOB 1057/4885ALDH1A1 1231/4885 |
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, C1R, C3AR1 | MAOA 574/4885MAOB 441/4885ALDH1A1 3277/4885 |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | CBR1, AFF1, ALK | MAOA 1976/4885MAOB 1625/4885ALDH1A1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.