Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496288 | 0.78 | CTDSP1 (0.43) | CYP1A2CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL7790927 | 0.75 | RAB9A (0.59) | MAPK1HPGDPOLBALDH1A1NPC1 | |
| SCHEMBL20703021 | 0.73 | CTDSP1 (0.55) | CYP1A2CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL25377449 | 0.71 | TRPM8 (0.57) | MAPTALDH1A1TSHRLMNACTDSP1 | |
| SCHEMBL26665546 | 0.70 | ALDH1A1 (0.42) | CYP2D6MAPTPOLBALDH1A1TSHR | |
| SCHEMBL20794554 | 0.70 | HTR2C (0.43) | POLBALDH1A1KDM4E | |
| SCHEMBL4496286 | 0.69 | POLB (0.49) | CYP1A2CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL25376641 | 0.69 | SLC6A2 (0.50) | MAPTMAPK1POLBALDH1A1LMNA | |
| SCHEMBL25377037 | 0.69 | SLC6A2 (0.50) | CYP1A2CYP3A4CYP2D6MAPTCYP2C19 | |
| SCHEMBL7890254 | 0.68 | CA12 (0.51) | MAPTMAPK1HPGDALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619086-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20080139579-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-06-12 | — | — | US | disclosed |
| EP-1725535-A2 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005086700-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139579-A1 | Hiv Integrase Inhibitors | INTS9, CDK9, PRDM9 | CYP1A2 2511/4885CYP3A4 782/4885CYP2D6 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.